When patients complain of vague constitutional symptoms that worsen over the course of the week and improve over the weekend, environmental/occupational exposures are at the top of the differential. You should make yourself aware of your work/living environment and determine if there are any pesticides, toxins, etc. that you may be exposed to near the end of the week.
Oftentimes, patients working in industries such as paint, textiles, printing, etc. are exposed to toxins that build up in their symptoms over the course of the week causing them to feel ill. Over the weekends, when they’re not at work, their bodies are able to excrete the toxins and their symptoms improve.
If your symptoms do not improve, then visiting your primary care physician for a physical exam or laboratory testing is warranted.
